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Monday 6 August 2012

Who Invented Tramadol and What Are Their Other Claims to Fame?

Tramadol, also found under the label names Rybix ODT, Ryzolt and Ultram, is a prescription analgesic medication used to treat moderate to severe pain. This medication is in a class of drugs known as opiates and include Demerol and morphine and works by altering the brain’s interpretation of pain. Because it is an opiate medication, Tramadol can be habit-forming however if taken as directed by a healthcare professional, Tramadol is generally safe and effective.
Potential side effects of Tramadol include fatigue, mood fluctuations and constipation. Most side effects are relatively mild and subside as your body becomes acclimated to the medication. Individuals taking this medication should exercise caution when operating heavy machinery and should avoid consuming grapefruit juice which can cause a serious interaction.
The manufacturer behind Tramadol is Ortho-McNeil-Janssen Pharmaceuticals, a pharmaceutical research and manufacturing company based in the United States. Ortho-McNeil-Janssen Pharmaceuticals’ primary emphasis is on developing medications used in pain management, acid reflux and infectious bacterial diseases.
Ortho-McNeil-Janssen Pharmaceuticals is responsible for the creation of several popular medications for pain management, aside from Tramadol. The widely used Duragesic patch is an opioid delivery dermal bandage that provides the medication fentanyl via slow absorption through the skin. The advantage to this method of delivery is that the medication is continuously provided to the patient and does not require regular consumption of medication in pill form.
In addition to Tramadol and Duragesic, Ortho-McNeil-Janssen Pharmaceuticals also produces combination pain medications that contain opiates including Tylenol with codeine, Tylox (oxycodone and acetaminophen) and a version of Ultram that also contains acetaminophen. Another medication this manufacturer offers is Parafon forte, a combination pain reliever that contains the muscle relaxer chlorzoxazone combined with acetaminophen. Finally, the company also manufacturers Nucynta (tapentadol), which is indicated for moderate to severe pain and affects both the ascending and descending neural pathways that create the sensation of pain. This is a unique action, in contrast to other opioid medications which only affect the ascending pathways.
In addition to medications intended for pain management, Ortho-McNeil-Janssen Pharmaceuticals also produces Aciphex (rabeprazole sodium). This medication is used to treat symptoms of heartburn and acid reflux and works by reducing the amount of stomach acid that reaches the esophagus. This action also helps to reduce erosion in the esophagus caused by continuous exposure to acid that can cause ulcers.
For the treatment of bacterial and fungal infections, Ortho-McNeil-Janssen Pharmaceuticals manufacturers injectable Doribax injectable antibiotic, Levaquin injectable antibiotic, Floxin tablets for ear infection, Nizoral antifungal cream, Sporanox antifungal capsules. The company was also the manufacturer of Propulsid, a popular medication used to treat stomach ulcers and acid reflux. Propulsid however, is no longer available for use in the United States.

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